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Annual Research & Review in Biology

Annual Research & Review in Biology, ISSN: 2347-565X,Vol.: 9, Issue.: 2

 

Case Study

 

Phylogenetic Considerations in the Evolutionary Development of Aminoglycoside Resistance Genes in Pathogenic Bacteria

 

 

Tommy Rodriguez1*

1Department of Research and Development, Pangaea Biosciences, Miami, FL, USA.

 

Abstracts

 

This study revisits antibiotic resistance as a source of evolutionary development in pathogenic bacteria. By taking a molecular phylogenetic approach to this inquiry, I seek to find homologous correlations in antimicrobial resistance gene families across a broad spectrum of bacteria, as to identify the possible acquisition of those genes through divergent events in evolutionary context. In order to test this, I examine the various degrees of genetic similarity in two antimicrobial resistance genomic datasets, namely aadA1 & aadA2 aminoglycoside resistance genes, among bacteria that occur in a multitude of environments. Moreover, the results from phylogenetic analysis suggests that pathogenic antibiotic resistance for aadA1 & aadA2 aminoglycoside resistance genes may have been acquired through evolutionary events with a common ancestor of a soil-dwelling bacterium.

 

Keywords :

Bacteria; pathogens; phylogeny; molecular phylogenetics; aminoglycoside resistance genes; antimicrobial resistance; multiple sequence alignment; comparative genomics.

 

Full Article - PDF    Page 1-8    Article Metrics

 

DOI : 10.9734/ARRB/2016/22895

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