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Annual Research & Review in Biology, ISSN: 2347-565X,Vol.: 4, Issue.: 15 (01-15 August)

Case Study

Oral Adverse Reaction to Cefuroxime Axetil


V. Vucicevic Boras1*, V. Brailo1, D. Vidovic Juras1, S. Ljubojevic Hadzavdic2 and D. Gabric Panduric3

1Department of Oral medicine, School of Dentistry, University of Zagreb and Clinical Hospital Center Rebro, Kispaticeva 12, Zagreb, Croatia.
2Clinic for Dermatology, Clinical Hospital Center Rebro, Kispaticeva 12, Zagreb, Croatia.
3Department of Oral Surgery, School of Dentistry, University of Zagreb, Croatia.


(1) Prof. George Perry,Dean and Professor of Biology, University of Texas at San Antonio, USA.


(1) Anonymous.

(2) Anonymous.

Complete Peer review History: http://www.sciencedomain.org/review-history/4345


A 62 year old female patient was referred to the Department of oral medicine due to the severe oral reaction two days after she started to use cefuroxime axetil. Buccal and sublingual mucosa was very inflamed and covered with thick pseudomembranes. Patient was otherwise healthy and did not take any medication. She was advised to stop the suspected drug intake immediately and was given intramuscular methylprednisolone injection (40mg, i.e. 1mg/kg) as well as chlorhexetidine mouthwash with local anaesthetic (Xylocaine) to be used at home three times a day. After seven days the lesions healed completely. Two months after the adverse drug side effect, allergic tests were performed. In vitro tests (indirect degranulation of basophile granulocytes and blast transformation of lymphocytes) as well asepicutaneous test were negative to cefuroxime axetil.

Keywords :

Cefuroxime axetil; oral adverse reaction.

Full Article - PDF    Page 2471-2475

DOI : 10.9734/ARRB/2014/10103

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