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Journal of Applied Life Sciences International, 2394-1103,Vol.: 4, Issue.: 4


Chemical Elemental Content/Calcium Ratios in Tissues of Human Hyperplastic Prostate Gland


V. Zaichick1* and S. Zaichick2

1Department of Radionuclide Diagnostics, Medical Radiological Research Centre, Obninsk, Russia. 

2Department of Medicine, University of Illinois, College of Medicine at Chicago, Chicago, USA.

Article Information
(1) Shahla Alalaf, Department of Obstetrics and Gynaecology, College of Medicine, Hawler Medical University, Iraq.
(1) Mine Kucur, Istanbul University, Turkey.
(2) K. S. Adedapo, University of Ibadan, Nigeria.
Complete Peer review History: http://sciencedomain.org/review-history/13640


Aims: The aim of this exploratory study was to evaluate whether significant deficiencies in the prostatic tissue levels of Ca and Mg, as androgen dependent chemical elements, and Br, K, Mn, and Na, as androgen independent chemical elements, exist in patients with BPH.

Methodology: It was prospectively evaluated prostatic tissue levels of these chemical elements in 27 patients with BPH and 37 healthy male inhabitants. Measurements were performed using instrumental neutron activation analysis with high resolution spectrometry of short-lived radionuclides. Beside the measurements of Br, Ca, K, Mg, Mn, and Na mass fraction the calculations of Br/Ca, K/Ca, Mg/Ca, Mn/Ca, and Na/Ca mass fraction ratios were also performed.

Results: There was no found significant difference in levels of Br, Ca, Mg, Mn, and Na contents between BPH and intact prostate. In the hyperplastic prostates, we have only observed a significant increase in value of K mass fraction (p<0.0014) and K/Ca mass fraction ratio (p<0.042).

Conclusion: The potential role of age-related chemical elements deficiency in the prostate was not confirmed as being involved in the etiology of BPH. It was hypothesized that not only a high level of some chemical elements, but also a great disturbance in the relationships of chemical elements in prostate tissue may serve as a pathogenetic factor of BPH.

Keywords :

Human prostate; chemical elements contents and relationships in prostate; benign prostate hyperplasia; chemical element supplementations.

Full Article - PDF    Page 1-11

DOI : 10.9734/JALSI/2016/24747

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